Blog
Vitamin B6 Toxicity: When a Nerve Vitamin Harms Nerves
Vitamin B6 toxicity is nerve damage caused by taking too much B6 over time. The adult upper limit is 100 mg a day, set to prevent sensory neuropathy. Symptoms such as tingling and numbness usually ease after the vitamin is stopped. Check the B6 in every product you take.
Written by the Nervecept label deskUpdated · 4 min read
What is vitamin B6 toxicity?
Vitamin B6 toxicity is sensory neuropathy caused by long-term high intake of B6 from supplements. NINDS lists excess B6 among the causes of peripheral neuropathy (NINDS, Peripheral Neuropathy).
B6 is a needed vitamin. The problem is the amount. The NIH Office of Dietary Supplements sets the adult upper limit at 100 mg a day to prevent this nerve damage (NIH ODS, Vitamin B6).
| Measure | Amount |
|---|---|
| Adult RDA | 1.3 to 1.7 mg a day |
| Upper limit | 100 mg a day |
| Severe neuropathy in long-term reports | 1 to 6 g a day |
| Some reports of neuropathy | Below 500 mg a day |
One gram is 1,000 mg. So the severe cases involved at least ten times the upper limit.
What has Australia's TGA said about vitamin B6?
Australia's drug regulator, the TGA, counted 250 reports of peripheral neuropathy or related terms linked to B6 products as of October 31, 2025 (TGA, Vitamin B6 safety update).
It then tightened the rules. Oral products over 50 mg and up to 200 mg a day become Pharmacist Only from June 1, 2027. Products over 200 mg stay prescription-only.
A rule from March 2022 makes products over 10 mg a day warn users to stop if tingling, burning or numbness occurs. That is a useful rule for anyone, anywhere. If a product makes your feet tingle, stop it and call your clinician.
How do you check all your products for vitamin B6?
Add up the B6 from every product that has a Supplement Facts panel. The risk comes from the total, not from one bottle.
Gather every bottle
Include multivitamins, B-complex products and anything sold for nerves or energy.
Find the B6 line
It may be listed as pyridoxine. Note the milligrams per serving.
Add the servings you take
Compare the daily total with 100 mg.
Ask a pharmacist
Bring the bottles if the total is close to or above the limit.
Do not stop a prescribed medicine on your own. Only supplements are in question here.
Does Nervecept contain vitamin B6?
No. The Nervecept label lists eight ingredients with exact amounts, and vitamin B6 is not one of them.
That means Nervecept adds nothing to your B6 total. It also means it is not a B vitamin product, despite the nerve wording on the front. It contains shellfish (crayfish), and it does not treat neuropathy.
All eight lines, with amounts, sit on the ingredients page. For the wider picture, read the nerve vitamins guide.
- 1Glucosamine Sulfate500 mg · 71.5% of the actives · Joint compounds
- 2Indian Frankincense (Boswellia serrata)(herb)67 mg · 9.6% of the actives · Plant extracts
- 3Chondroitin Sulfate50 mg · 7.2% of the actives · Joint compounds
- 4Turmeric (Curcuma longa)(root)50 mg · 7.2% of the actives · Plant extracts
- 5Quercetin (Sophora japonica)(bud)8 mg · 1.1% of the actives · Plant extracts
- 6Methionine8 mg · 1.1% of the actives · Amino acid
- 7Methylsulfonylmethane (MSM)8 mg · 1.1% of the actives · Sulfur compound
- 8Bromelain (Ananas comosus)(stem)8 mg · 1.1% of the actives · Plant extracts
From the Supplement Facts panel on the label: every line has an exact amount, and no line has a Daily Value. The capsule shell (hypromellose) and rice flour are not counted. The glucosamine is made from shellfish (crayfish).
FAQ01
Nervecept questions people ask
Can vitamin B6 from a multivitamin cause neuropathy?
It can if the total is high for a long time. The sources used here link nerve damage to supplement doses well above the 100 mg limit. Add up all products.
Does B6 neuropathy go away?
Symptoms usually resolve after stopping the supplement, per the NIH. Ask your clinician before you stop or restart anything.
What is pyridoxine?
Pyridoxine is a common form of vitamin B6 listed on supplement labels. Count it toward your B6 total.
Who wrote this02
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a Nervecept licensed U.S. outlet, not by the manufacturer or the distributor. We earn money when you buy through our order links.
Keep reading
More about Nervecept
Nervecept licensed U.S. outlet
Ready to try Nervecept?
Check the shellfish allergen and your medicines first, then pick a pack. Three or six bottles ship free in the US and cost less per bottle, with a 60-day money-back guarantee.
- Secure checkout on the sales page
- 60-day money-back guarantee
- Ships from the U.S.
